Ralph DaCosta

Dr. DaCosta discusses the origins of the lab and his serendipitous invention in UHN’s latest Behind the Breakthrough podcast episode
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Behind the Breakthrough, a podcast about the people behind the world-leading research at UHN, features Dr. Ralph DaCosta in Episode 7 of its second season. In this episode, Dr. DaCosta recollects his family’s immigration to Canada, his career path and serendipitous discovery that could revolutionize wound care. Hear about his groundbreaking work in visualizing cancer, his adventure becoming an inventor and entrepreneur, and how Terry Fox was the inspiration for his drive to enter cancer research.

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Dr. Ralph DaCosta joins UHN’s DORA Advisory Group
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In January, the Research Institutes at UHN signed the  San Francisco Declaration on Research Assessment (DORA), joining more than 1,500 institutions worldwide. DORA is a set of recommendations developed in 2012 by a group of editors and publishers of scholarly journals and is aimed at creating an improved and robust evaluation of the science and research impact of individuals and institutions. The UHN DORA Advisory Group was assembled to guide the implementation of these principles at the Research Institutes. This group is composed of a diverse group of PIs from across the seven UHN Research Institutes and will develop guidance…

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Engineering Functional Microvessels in Synthetic Polyurethane Random-Pore Scaffolds by Harnessing Perfusion Flow
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Wright ME, Yu JK, Jain D, Maeda A, Yeh SA, DaCosta R, Lin CP, Santerre JS; Biomaterials. 2020 Jun 23;256:120183
doi: 10.1016/j.biomaterials.2020.120183. Online ahead of print.

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Intraoperative Fluorescence Imaging with Aminolevulinic Acid Detects Grossly Occult Breast Cancer: a Phase II Randomized Controlled Trial (Conference Presentation)
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Ottolino-Perry K, Shahid A, DeLuca S, Son V, Liu Z, Rapic S, Thalanki Anantha NWang S, Chamma E, Blackmore K, Gibson C, Medeiros PJ, Majeed S, Chu A, Pizzolato A, Rosen CF, Lindvere-Teene L, Dunham D, Kulbatski I, Panzarella T, Done SJ, Easson AM, Leong WL, DaCosta RS; Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110701Y (14 August 2019)

doi.org/10.1117/12.2527216

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Intravital Imaging for Tracking of Angiogenesis and Cellular Events Around Surgical Bone Implants
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Khosravi N, Mendes VC, Nirmal G, Majeed S, DaCosta R, Davies J; Tissue Eng Part C Methods. 2018 Nov;24(11):617-627
doi: 10.1089/ten.TEC.2018.0252

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A Feasibility Study of Photoacoustic Imaging of Ex Vivo Endoscopic Mucosal Resection Tissues from Barrett’s Esophagus Patients
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Lim L, Streutker CJ, Marcon N, Cirocco M, Lao A, Iakovlev VV, DaCosta R, Wilson BC; Endosc Int Open. 2017 Aug;5(8):E775-E783
doi: 10.1055/s-0043-111790

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Improved Detection of Clinically Relevant Wound Bacteria Using Autofluorescence Image-Guided Sampling in Diabetic Foot Ulcers
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Ottolino-Perry K, Chamma E, Blackmore KM, Lindvere-Teene L, Starr D, Tapang K, Rosen CF, Pitcher B, Panzarella T, Linden R, DaCosta RS; Int Wound J. 2017 Oct;14(5):833-841
doi: 10.1111/iwj.12717

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Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging
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Stammes MA, Knol-Blankevoort VT, Cruz LJ, Feitsma HR, Mezzanotte L, Cordfunke RA, Sinisi R, Dubikovskaya EA, Maeda A, DaCosta RS, Bierau K, Chan A, Kaijzel EL, Snoeks TJ, van Beek ER, Löwik CW; Mol Imaging Biol. 2016 Dec;18(6):905-915
doi.org/10.1007/s11307-016-0972-7

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The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death
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Stammes MA, Maeda A, Bu J, Scollard DA, Kulbatski I, Medeiros PJ, Sinisi R, Dubikovskaya EA, Snoeks TJ, van Beek ER, Chan AB, Löwik CW, DaCosta RS; Front Oncol. 2016 Oct 21;6:221
doi: 10.3389/fonc.2016.00221

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