Hot off the Press! Intraoperative Fluorescence Imaging with Aminolevulinic Acid Decets Grossly Occult Breast Cancer: A Phase II Randomized Controlled Trial is published in Breast Cancer Research

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After a lengthy journey, our paper “Intraoperative fluorescence imaging with aminolevulinic acid detects grossly occult breast cancer: a phase II randomized controlled trial” has been published in Breast Cancer Research as an open access article. The journal is widely read globally by general surgeons and breast cancer clinicians, so we are pleased it will receive broad…

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Welcome 2021 Summer Students!

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We would like to welcome 5 high school and undergraduate summer students who will be joining the lab this year: Ben Daynes (Aurora High School, Grade 12) Project: Developing health monitoring spectrometer with built-in light source for detection of urine biomarkers. Rachel Jacobson (Wilfred Laurier University, 1st year) Project: Investigating immunotherapy in acute myelogenous leukemia.…

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Dr. DaCosta to Deliver Keynote Presentation at St Michael’s 4th Annual Life Sciences Career Symposium

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The St. Michael’s Hospital Research Student Association’s annual Life Sciences Career Symposium aims to connect trainees to distinguished experts in the Life Sciences. This year’s Symposium will take place on July 9th, 2021, featuring keynote speakers Dr. Samantha Yammine and Dr. Ralph DaCosta. Dr.DaCosta will headline the Biotechnology and Innovation session (1-3PM), sharing his experiences…

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Dr. DaCosta participates in Annual 2021 MBP Career Symposium

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The annual MBP Symposium (which combines the James Lepock Memorial (JLM) Symposium and the annual MBP Alumni Night) is an important MBP event that provides an opportunity for MBP students to present their research in a conference setting. The MBP Symposium fosters scientific debate across disciplines, streams and institutes. MBP students have the opportunity to…

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Dr. Niloufar Khosravi featured on U of T Faculty of Dentistry Website

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Niloufar Khosravi, a DaCosta Lab PhD student alumna was recently featured on U of T’s Faculty of Dentistry site. In the Article, “U of T Researchers Map Regenerative Cells in Implant Wounds” Niloufar summarized her work recently published in Biomaterials.

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Intraoperative Fluorescence Imaging with Aminolevulinic Acid Detects Grossly Occult Breast Cancer: A Phase II Randomized Controlled Trial: Manuscript accepted to Breast Cancer Research

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In 2009, the first patient was enrolled at Princess Margaret Cancer Center in this Phase II randomized controlled trial led by Dr. DaCosta in collaboration with surgeons Drs. Wey Leong and Alexandra Easson and pathologist Dr. Susan Done. The goal was to evaluate the clinical safety, feasibility and diagnostic performance of the PRODIGI handheld fluorescence…

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World’s 1st Patient Surgery in Pivotal Phase III breast cancer trial

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  Today marks an important milestone for SBI Canada’s Phase III RCT entitled “Fluorescence Imaging of Carcinoma During Breast Conserving Surgery”, as the first patient surgery was performed successfully at Orlando Health in Orlando, Florida. (ClinicalTrials.gov Identifier: NCT04815083) This trial utilizes the tumor selectivity of 5-ALA combined with the handheld Eagle fluorescence imaging device to…

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Helen Jin is going to Medical School!

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We would like to congratulate Helen Jin on her acceptance into the University of Western Ontario MD Program, knowing she was also accepted to several other prestigious MD programs across Canada. Helen joined the DaCosta Lab in 2019 to pursue her MSc in the Department of Medical Biophysics, UofT and will be graduating in June…

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World’s 1st Patient Enrolled in International FDA Approved Phase III RCT of Breast Cancer Surgery

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Today, SBI ALApharma Canada Inc., a subsidiary of photonamic GmbH & Co. KG (Pinneberg, Germany), a subsidiary of SBI Holdings, Inc. (Minato-ku, Tokyo) announced it has enrolled the first patient in its Pivotal Phase III randomized controlled trial evaluating the safety and efficacy of PD G 506 A (5-ALA HCl) in margin assessment during breast…

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Fluorescence-Guided Breast Cancer Surgery: International Pivotal Phase III RCT receives FDA IND Clearance

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Today, SBI ALApharma Canada Inc., a subsidiary of photonamic GmbH & Co. KG ( Pinneberg, Germany), a subsidiary of SBI Holdings, Inc. (Minato-ku, Tokyo); received FDA Investigational New Drug (IND) clearance for its Pivotal Phase III randomized controlled trial (RCT) evaluating the safety and efficacy of PD G 506 A (5-ALA HCl) in intraoperative margin assessment during…

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