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  • Team
    • Dr. Ralph S. DaCosta
    • Team
  • Research
    • Preclinical Research
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    • Clinical Trials
    • Facilities & Resources
    • Collaborators
    • Funding
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Assessing the Accuracy of Bioluminescence Image-Guided Stereotactic Body Radiation Therapy of Orthotopic Pancreatic Tumors Using a Small Animal Irradiator

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April 14, 2022

Our recent publication in Radiation Research, “Assessing the Accuracy of Bioluminescence Image-Guided Stereotactic Body Radiation Therapy of Orthotopic Pancreatic Tumors Using a Small Animal Irradiator” is a collaboration between the DaCosta Lab and Dr. Robert Weersink. In this preclincal study, Dr. Sara Rapic (former Post-doctoral fellow) and Timothy Samuel (Ph.D. candidate) demonstrated the improved accuracy of using 3-dimensional bioluminescence imaging (BLI) to deliver targeted high dose radiotherapy in orthotopic mouse models of pancreatic cancer. This BLI image-guided precision in the delivery of radiation therapy to pancreatic tumors in vivo ensures the precision of the treatment using a novel small animal irradiator. This methodology allows us to investigate the response of these tumors, their vasculature and microenvironment to radiation therapy tailored to simulate clinical radiotherapy regimes in patients. This technology is also helping to expand our understanding of tumor hypoxia in pancreatic cancer and how hypoxia can impact tumor response as well as modify the tumor microenvironment over time.  Currently, this platform is being used to study the relationship between pancreatic tumor cell hypoxia and changes in tumor-associated stromal cells in vivo in the orthotopic setting by exploiting our intravital fluorescence imaging platform with and without radiation treatment. Representation of image collection workflow showing: CBCT (panel A), white light (panel B), and 3D surface mesh (panel C) images overlayed with the bioluminescence image of an anesthetized mouse previously injected with luciferin. The bioluminescence signal (red . High signal, blue . low signal) occurs from the pancreatic tumor, which cannot be seen in the CBCT image only. All images are co-registered automatically since the modules are integrated into the same gantry without the need to move the mouse. The optical point source (black arrow) is calculated from the bioluminescence signal and targeted (blue crosshairs) for radiation (panel D). MRI-guided targeting (panel E; yellow crosshairs) is done after co-registration of a sequentially acquired magnetic resonance (purple) and CBCT image (green). Although the same imaging bed is used, the mouse is allowed to wake up between the scans, requiring manual registration. Scale bars = 1 cm The X-RAD 225Cx’s capability to acquire bioluminescence images allows for functional analysis of tumor viability. Scaled bioluminescence images (normalized for exposure time) overlayed with their co-registered CBCT scan are shown for a representative animal in each group before treatment and when receiving their third fraction and last fraction (panel A). Panel B: Maximum photon counts after 5 fractions of SBRT (D5) for the control, BLI-guided, and MRI-guided SBRT groups. The optical signal was the lowest when BLI was used to guide the Xray dose to the tumor. When the X-ray dose was guided to the tumor in the magnetic resonance image co-registered with the CBCT scan, the optical signal was comparable to that of the untreated group (panel C) Tumor volume, as determined from the excised tumor after the last fraction using a digital caliper, did not differ between groups, but a slight reduction was observed in SBRT-treated groups, albeit not significantly.

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Intraoperative Fluorescence Imaging with Aminolevulinic Acid Decets Grossly Occult Breast Cancer: A Phase II Randomized Controlled Trial is published in Breast Cancer Research

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July 21, 2021

After a lengthy journey, our paper “Intraoperative fluorescence imaging with aminolevulinic acid detects grossly occult breast cancer: a phase II randomized controlled trial” has been published in Breast Cancer Research as an open access article. The journal is widely read globally by general surgeons and breast cancer clinicians, so we are pleased it will receive broad clinical exposure and impact specifically in (breast) surgical oncology. This trial, led by Dr. DaCosta, was conducted at The Princess Margaret Cancer Center (Toronto, Canada) and demonstrates the importance of strong collaborations between our (imaging) scientists and clinicians at the Princess Margaret Cancer Center.  For example, without the commitment and support of our surgeons (Drs. Wey Leong, Alexandra Easson and others) and our pathologist (Dr. Susan Done), we could never have reached this important result. Indeed, they and other Princess Margaret clinicians will soon join our large ongoing North American FDA IND-approved Pivotal Phase 3 RCT as we add PMCC to our growing list of Phase 3 trial sites. Future plans are in progress to expand this line of research to other cancers e.g. head & neck, cervical and lung where real-time intraoperative margin assessment is important.

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Intraoperative Fluorescence Imaging with Aminolevulinic Acid Detects Grossly Occult Breast Cancer: A Phase II Randomized Controlled Trial: Manuscript accepted to Breast Cancer Research

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May 24, 2021

In 2009, the first patient was enrolled at Princess Margaret Cancer Center in this Phase II randomized controlled trial led by Dr. DaCosta in collaboration with surgeons Drs. Wey Leong and Alexandra Easson and pathologist Dr. Susan Done. The goal was to evaluate the clinical safety, feasibility and diagnostic performance of the PRODIGI handheld fluorescence imaging device combined with 5-ALA HCl for intraoperative visualization of invasive breast carcinomas. The Phase II trial was supported in large part by a $3M CIHR grant awarded to the DaCosta lab. Today, over a decade later, the manuscript for this study was accepted for publication in Breast Cancer Research. This publication is the clinical report of visualization of 5-ALA HCl-induced fluorescence in breast carcinomas, including invasive lobular and ductal carcinoma in situ using the original DaCosta lab prototype handheld intraoperative fluorescence imaging device called “PRODIGI”. After many years, the PRODIGI device has evolved into a state-of-the-art fully handheld intraoperative fluorescence imaging technology called “Eagle”. Currently, the collaboration with Drs. Leong, Easson, Done and others at the Princess Margaret Cancer Center has evolved into a new clinical trial called “RESTART” at Princess Margaret Cancer Center. This trial will test 5-ALA with a the Eagle imaging technology to study the biological mechanisms of 5-ALA-induced PpIX fluorescence specificity across various breast cancer subtypes in contrast with healthy tissues. (ClinicalTrials.gov Identifier: NCT01837225). The DaCosta lab recognizes the incredible collaborative spirit of PMCC clinicians that helps to drive translation (cancer imaging) research forward to the international stage.  Without the excitement and durable support of our clinician partners, we would not have been able to reach these important milestones as we try to overcome the challenges of cancer surgery for patients around the globe. View on PubMed

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In Vivo Mesenchymal Progenitor Cell Dynamics: Dr. Niloufar Khosravi publishes in Biomaterials

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April 20, 2021

Niloufar Khosravi, a DaCosta Lab PhD student alumna, published in Biomaterials today: “New insights into spatio-temporal dynamics of mesenchymal progenitor cell ingress during peri implant wound healing: Provided by intravital imaging”. Abstract Surface topography drives the success of orthopedic and dental implants placed in bone, by directing the biology occurring at the tissue-implant interface. Over the last few decades, striking advancements have been made in the development of novel implant surfaces that enhance bone anchorage to their surfaces through contact osteogenesis: the combination of the two phenomena of recruitment and migration of mesenchymal progenitor cells to the implant surface, and their differentiation into bone-forming cells. While the latter is generally understood, the mechanisms and dynamics underlying the migration and recruitment of such progenitor cells into the wound site have garnered little attention. To address this deficit, we surgically inserted metallic implants with two different surface topographies into the skulls of mice, and then employed real-time spatiotemporal microscopic monitoring of the peri-implant tissue healing to track the ingress of cells. Our results show that nanotopographically complex, in comparison to relatively smooth, implant surfaces profoundly affect recruitment of both endothelial cells, which are essential for angiogenesis, and the mesenchymal progenitor cells that give rise to the reparative tissue stroma. The latter appear concomitantly in the wound site with endothelial cells, from the vascularized areas of the periosteum, and demonstrate a proliferative “bloom” that diminishes with time, although some of these cells differentiate into important stromal cells, pericytes and osteocytes, of the reparative wound. In separate experiments we show, using trajectory plots, that the directionality of migration for both endothelial and perivascular cells can be explained by implant surface dependent release of local cytokine gradients from platelets that would become activated on the implant surfaces during initial blood contact. These findings provide new biological insights into the earliest stages of wound healing, and have broad implications in the application of putative nano-topographically complex biomaterials in many tissue types.

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Engineering Functional Microvessels in Synthetic Polyurethane Random-Pore Scaffolds by Harnessing Perfusion Flow

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June 23, 2020

Wright ME, Yu JK, Jain D, Maeda A, Yeh SA, DaCosta R, Lin CP, Santerre JS; Biomaterials. 2020 Jun 23;256:120183
doi: 10.1016/j.biomaterials.2020.120183. Online ahead of print.

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Intraoperative Fluorescence Imaging with Aminolevulinic Acid Detects Grossly Occult Breast Cancer: a Phase II Randomized Controlled Trial (Conference Presentation)

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August 14, 2019

Ottolino-Perry K, Shahid A, DeLuca S, Son V, Liu Z, Rapic S, Thalanki Anantha N, Wang S, Chamma E, Blackmore K, Gibson C, Medeiros PJ, Majeed S, Chu A, Pizzolato A, Rosen CF, Lindvere-Teene L, Dunham D, Kulbatski I, Panzarella T, Done SJ, Easson AM, Leong WL, DaCosta RS; Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110701Y (14 August 2019)

doi.org/10.1117/12.2527216

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Intravital Imaging for Tracking of Angiogenesis and Cellular Events Around Surgical Bone Implants

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November 1, 2018

Khosravi N, Mendes VC, Nirmal G, Majeed S, DaCosta R, Davies J; Tissue Eng Part C Methods. 2018 Nov;24(11):617-627
doi: 10.1089/ten.TEC.2018.0252

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Nanosurfaces Modulate the Mechanism of Peri-Implant Endosseous Healing by Regulating Neovascular Morphogenesis

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June 1, 2018

Khosravi N, Maeda A, DaCosta RS, Davies JE; Nat Comm Bio. 72(1):2399-3642
doi: 10.1038/s42003-018-0074-y

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A Feasibility Study of Photoacoustic Imaging of Ex Vivo Endoscopic Mucosal Resection Tissues from Barrett’s Esophagus Patients

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August 7, 2017

Lim L, Streutker CJ, Marcon N, Cirocco M, Lao A, Iakovlev VV, DaCosta R, Wilson BC; Endosc Int Open. 2017 Aug;5(8):E775-E783
doi: 10.1055/s-0043-111790

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Improved Detection of Clinically Relevant Wound Bacteria Using Autofluorescence Image-Guided Sampling in Diabetic Foot Ulcers

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February 28, 2017

Ottolino-Perry K, Chamma E, Blackmore KM, Lindvere-Teene L, Starr D, Tapang K, Rosen CF, Pitcher B, Panzarella T, Linden R, DaCosta RS; Int Wound J. 2017 Oct;14(5):833-841
doi: 10.1111/iwj.12717

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Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging

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December 18, 2016

Stammes MA, Knol-Blankevoort VT, Cruz LJ, Feitsma HR, Mezzanotte L, Cordfunke RA, Sinisi R, Dubikovskaya EA, Maeda A, DaCosta RS, Bierau K, Chan A, Kaijzel EL, Snoeks TJ, van Beek ER, Löwik CW; Mol Imaging Biol. 2016 Dec;18(6):905-915
doi.org/10.1007/s11307-016-0972-7

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The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death

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October 21, 2016

Stammes MA, Maeda A, Bu J, Scollard DA, Kulbatski I, Medeiros PJ, Sinisi R, Dubikovskaya EA, Snoeks TJ, van Beek ER, Chan AB, Löwik CW, DaCosta RS; Front Oncol. 2016 Oct 21;6:221
doi: 10.3389/fonc.2016.00221

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Hybrid Manganese Dioxide Nanoparticles Potentiate Radiation Therapy by Modulating Tumor Hypoxia

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October 6, 2016

Abbasi AZ, Gordijo CR, Amini MA, Maeda A, Rauth AM, DaCosta RS, Wu XY; Cancer Res. 2016 Nov 15;76(22):6643-6656
doi: 10.1158/0008-5472.CAN-15-3475.

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In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model

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September 14, 2016

Maeda A, Chen Y, Bu J, Mujcic H, Wouters BG, DaCosta RS; Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):184-194
doi: 10.1016/j.ijrobp.2016.09.005

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Can Imaging Put the “Advanced” Back in Advanced Wound Care?

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August 1, 2016

DaCosta RS, Ottolino-Perry K, Banerjee J; Adv Wound Care (New Rochelle). 2016 Aug 1;5(8):329-331
doi: 10.1089/wound.2016.0702

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Femur Window Chamber Model for In Vivo Cell Tracking in the Murine Bone Marrow

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July 28, 2016

Chen Y, Maeda A, Bu J, DaCosta RS; J Vis Exp. 2016 Jul 28;(113)
doi: 10.3791/54205.

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Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology

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September 1, 2015

Maeda A, Kulbatski I, DaCosta RS; Mol Imaging. 2015 Sep 1;14:452-74
doi.org/10.2310/7290.2015.00022

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Optically-Tracked Handheld Fluorescence Imaging Platform for Monitoring Skin Response in the Management of Soft Tissue Sarcoma

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July 1, 2015

Chamma E, Qiu J, Lindvere-Teene L, Blackmore KM, Majeed S, Weersink R, Dickie CI, Griffin AM, Wunder JS, Ferguson PC, DaCosta RS; J Biomed Opt. 2015 Jul 1;20(7):76011
doi: 10.1117/1.JBO.20.7.076011

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Handheld Fluorescence Imaging Device Detects Subclinical Wound Infection in an Asymptomatic Patient with Chronic Diabetic Foot Ulcer: a Case Report

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April 15, 2015

Wu YC, Smith M, Chu A, Lindvere-Teene L, Starr D, Tapang K, Shekhman R, Wong O, Linden R, DaCosta RS; Int Wound J. 2016 13(4):449-53
doi: 10.1111/iwj.12451

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A Prototype Hand-Held Tri-Modal Instrument for In Vivo Ultrasound, Photoacoustic, and Fluorescence Imaging

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March 27, 2015

Kang J, Chang JH, Wilson BC, Veilleux I, Bai Y, DaCosta RS, Kim K, Ha S, Lee JG, Kim JS, Lee S, Kim SM, Lee HJ, Ahn YB, Han S, Yoo Y and Song T; Rev. Sci. Instrum. 2015 (86)034901
doi.org/10.1063/1.4915146

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Point-of-Care Autofluorescence Imaging for Real-Time Sampling and Treatment Guidance of Bioburden in Chronic Wounds: First-in-Human Results

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March 19, 2015

DaCosta RS, Kulbatski I, Lindvere-Teene L, Starr D, Blackmore K, Silver JI, Opoku J, Wu YC, Medeiros PJ, Xu W, Xu L, Wilson BC, Rosen C, Linden R; PLoS ONE 10(3): e0116623
doi.org/10.1371/journal.pone.0116623

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Design of Hybrid MnO2-Polymer-Lipid Nanoparticles with Tunable Oxygen Generation Rates and Tumor Accumulation for Cancer Treatment,

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February 18, 2015

Gordijo CR, Abbasi AZ, Amini MA, Lip HY, Maeda A, Cai P, O’Brien PJ, DaCosta RS, Rauth AM and Wu XY; Advanced Functional Materials. 2015;25(12):1858–1872
doi.org/10.1002/adfm.201404511

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Dual In Vivo Photoacoustic and Fluorescence Imaging of HER2 Expression in Breast Tumors for Diagnosis, Margin Assessment, and Surgical Guidance

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November 1, 2014

Maeda A, Bu J, Chen J, Zheng G, DaCosta RS; Mol Imaging 2014;13(0):1-9
doi: 10.2310/7290.2014.00043

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A Multifunctional Polymeric Nanotheranostic System Delivers Doxorubicin and Imaging Agents Across the Blood-Brain Barrier Targeting Brain Metastases of Breast Cancer

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October 13, 2014

Li J, Cai P, Shalviri A, Henderson JT, He C, Foltz WD, Prasad P, Brodersen PM, Chen Y, DaCosta R, Rauth AM, Wu XY; ACS Nano. 2014 Oct 28;8(10):9925-40
doi: 10.1021/nn501069c

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Autofluorescence Imaging Device for Real-Time Detection and Tracking of Pathogenic Bacteria in a Mouse Skin Wound Model: Preclinical Feasibility Studies

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August 19, 2014

Wu YC, Kulbatski I, Medeiros PJ, Maeda A, Bu J, Xu L, Chen Y,DaCosta RS; J Biomed Opt. 2014 Aug;19(8):085002
doi: 10.1117/1.JBO.19.8.085002

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Multifunctional Albumin Based MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, VEGF and Enhance Radiation Response

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April 4, 2014

Prasad P, Gordijo CR, Abbasi AZ, Maeda A, Ip A, Rauth AM, DaCosta RS and Wu XY; ACS Nano. 2014 8 (4), 3202-3212
doi: 10.1021/nn405773r

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Tumour Vascularization is Critical for Oncolytic Vaccinia Virus Treatment of Peritoneal Carcinomatosis

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February 1, 2014

Ottolino-Perry K, Tang N, Head R, Ng C, Angarita FC, Acuna SA, DaCosta RS and McCart JA; Int J Cancer. 2014;134(3):717-30

doi.org/10.1002/ijc.28395

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Advanced Imaging Technologies for the Detection of Dysplasia and Early Cancer in Barrett Esophagus

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January 24, 2014

Espino A, Cirocco M, DaCosta RS, Marcon N; Clin Endosc. 2014 47(1): 47–54
doi:10.5946/ce.2014.47.1.47

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Optimization of the Dorsal Skinfold Window Chamber Model and Multi-Parametric Characterization of Tumor-Associated Vasculature

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January 1, 2014

Maeda A, DaCosta RS; Intravital. 2014 Feb 4;3(1):e27935
doi:10.4161/intv.27935

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Endoscopic Mucosal Imaging of Gastrointestinal Neoplasia in 2013

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July 15, 2013

Urquart P, DaCosta RS, Marcon NE; Curr Gastroenterol Rep. 2013;15(7):330
doi: 10.1007/s11894-013-0330-8

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A Novel High-Resolution In Vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

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June 16, 2013

Burrell K, Agnihotri S, Leung M, DaCosta RS, Hill RP, Zadeh G; J. Vis. Exp. 2013;(76), e50363
doi:10.3791/50363

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Texture Analysis of OCT Speckle for Characterizing Biological Tissues In Vivo

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April 15, 2013

A.A. Lindenmaier, L. Conroy, R.S. DaCosta, C. Flueraru, I.A. Vitkin; Opt Lett. 2013;38(8):1280-2

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Texture Analysis of Optical Coherence Tomography Speckle for Characterizing Biological Tissues In Vivo

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April 15, 2013

Lindenmaier AA, Conroy L, Farhat G, DaCosta RS, Flueraru C, Vitkin A; Opt Lett. 2013;38(8):1280-2
doi:10.1364/OL.38.001280

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Serum-Free Differentiation of Functional Human Coronary-Like Vascular Smooth Muscle Cells from Embryonic Stem Cells

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April 1, 2013

El-Mounayri O, Mihic A, Shikatani A, Gagliardi M, Dubois N, DaCosta RS, Li RK, Keller G, Husain M; Cardiovasc Res. 2013;98(1):125-35
doi:10.1093/cvr/cvs357

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A Spinal Cord Window Chamber Model for In Vivo Longitudinal, Multimodal Optical Imaging in a Mouse Model

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March 14, 2013

Figley SA, Chen Y, Maeda A, Conroy L, McMullen JD, Silver JI, Stapleton S, Vitkin A, Zadeh G, Burrell K, Fehlings MG, DaCosta RS. PLoS One. 2013;8(3):e58081
doi:10.1371/journal.pone.0058081

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Displaying 3D Radiation Dose on Endoscopic Video for Therapeutic Assessment and Surgical Guidance

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October 21, 2012

J. Qiu, A. Hope, J. Cho, M. Sharpe, C. Dickie, R.S. DaCosta, D.A. Jaffray and R. Weersink; Phys Med Biol. 2012;57(20):6601-14

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A Novel Solid Lipid Nanoparticle Formulation for Active Targeting to Tumor αvβ3 Integrin Receptors Reveals Cyclic RGD as a Double-Edged Sword

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September 12, 2012

A.J. Shuhendler, P. Prasad, M. Leung, A.M. Rauth, R.S. DaCosta, X.Y. Wu; Advanced Healthcare Materials. 2012; (5):600-8

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In Vivo Optical Imaging of Tumor and Microvascular Response to Ionizing Radiation

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August 22, 2012

A. Maeda, M.K.K. Leung, L. Conroy, Y. Chen, J. Bu, P.E. Lindsay, S. Mintzberg, C. Virtanen, J. Tsao, N.A. Winegarden, Y. Wang, L. Morikawa, I.A. Vitkin, D.A. Jaffray, R.P. Hill, R.S. DaCosta; PLoS ONE 2012;7(8)

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Quantifying Tissue Microvasculature with Speckle Variance Optical Coherence Tomography

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August 1, 2012

L. Conroy, R.S. DaCosta, I.A. Vitkin; Opt Lett. 2012;37(15):3180

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Estimation of Minimum Doses for Optimized Quantum Dot Contrast-Enhanced Vascular Imaging In Vivo

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June 11, 2012

M. Roy, C.J. Niu, Y. Chen, P.Z. McVeigh, A.J. Shuhendler, M.K.K. Leung, A. Mariampillai, R.S. DaCosta, B.C. Wilson; Small 2012;11:1780-92

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Improving Superficial Target Delineation in Radiation Therapy with Endoscopic Tracking and Registration

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December 12, 2011

Weersink RA, Qiu J, Hope AJ, Daly MJ, Cho EC, DaCosta RS, Sharpe MB, Breen SL, Chan H, Jaffray DA; Med Phys. 2011;38(12):6458
doi:10.1118/1.3658569

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Aberrant Axial Mineralization Precedes Spinal Ankylosis: a Molecular Imaging Study in Ank/Ank Mice

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October 12, 2011

Las Heras F, DaCosta RS, Pritzker KP, Haroon N, Netchev G, Tsui HW, Chiu B, Erwin WM, Tsui FW, Inman RD; Arthritis Res Ther. 2011;13(5):R163
doi:10.1186/ar3482
F Las Heras, R.S. DaCosta, K.P. Pritzker, N. Haroon, G. Netchev, H.W. Tsui, B. Chiu, W.M. Erwin, F.W. Tsui, R.D. Inman; Arthritis Res Ther. 2011;13(5):R163

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Directed Differentiation of Skin-Derived Precursors into Functional Vascular Smooth Muscle Cells

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August 18, 2011

Steinbach SK, El-Mounayri O, DaCosta RS, Frontini MJ, Nong Z, Maeda A, Pickering JG, Miller FD, Husain M; Arterioscler Thromb Vasc Biol. 2011;13(5):R163
doi:10.1161/ATVBAHA.111.232975

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Porphyrin-Cross-Linked Hydrogel for Fluorescence-Guided Monitoring and Surgical Resection

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July 21, 2011

Lovell JF, Roxin A, Ng KK, Qiaochu QQ, McMullen JD, DaCosta RS, Zheng G; Biomacromolecules. 2011;12(9):3115-8
doi:10.1021/bm200784s

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Design and Modeling of a Prototype Fiber Scanning CARS Endoscope

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February 24, 2010

Veilleux I, Doucet M, Coté P, Verreault S, Fortin M, Paradis P, Leclair S, DaCosta RS, Wilson BC, Seibel E, Mermut O, Cormier J; Design and modeling of a prototype fiber scanning CARS endoscope, Proc. SPIE 7558, Endoscopic Microscopy V, 75580D (24 February 2010)

doi:10.1117/12.842624

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Extending Immunofluorescence Detection Limits in Whole Paraffin-Embedded Formalin Fixed Tissues using Hyperspectral Confocal Fluorescence Imaging

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May 2, 2009

Constantinou P, DaCosta RS, Wilson BC; J Microsc. 2009;234:137-46
doi: 10.1111/j.1365-2818.2009.03155.x

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Integrated Biophotonics in Endoscopic Oncology

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February 24, 2009

Muguruma N, DaCosta RS, Wilson BC, Marcon NE; Integrated biophotonics in endoscopic oncology, Proc. SPIE 7170, Design and Quality for Biomedical Technologies II, 71700B (24 February 2009)
doi:10.1117/12.806591

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In Vivo Near-Infrared Fluorescence Imaging of Human Colon Adenocarcinoma by Specific Immunotargeting of a Tumor-Associated Mucin

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January 1, 2009

DaCosta RS, Tang Y, Kalliomaki T, RM Reilly, Weersink RA, Elford AR, Marcon NE, Wilson BC; Journal of Innovative Optical Health Sciences 2009; 2:1-16; Journal of Innovative Optical Health Sciences 2009; 2:1-16
doi:10.1142/S1793545809000759

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