Publications – DaCosta Lab

Engineering Functional Microvessels in Synthetic Polyurethane Random-Pore Scaffolds by Harnessing Perfusion Flow

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June 23, 2020

Wright ME, Yu JK, Jain D, Maeda A, Yeh SA, DaCosta R, Lin CP, Santerre JS; Biomaterials. 2020 Jun 23;256:120183
doi: 10.1016/j.biomaterials.2020.120183. Online ahead of print.

Intraoperative Fluorescence Imaging with Aminolevulinic Acid Detects Grossly Occult Breast Cancer: a Phase II Randomized Controlled Trial (Conference Presentation)

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August 14, 2019

Ottolino-Perry K, Shahid A, DeLuca S, Son V, Liu Z, Rapic S, Thalanki Anantha N, Wang S, Chamma E, Blackmore K, Gibson C, Medeiros PJ, Majeed S, Chu A, Pizzolato A, Rosen CF, Lindvere-Teene L, Dunham D, Kulbatski I, Panzarella T, Done SJ, Easson AM, Leong WL, DaCosta RS; Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110701Y (14 August 2019)

doi.org/10.1117/12.2527216

Intravital Imaging for Tracking of Angiogenesis and Cellular Events Around Surgical Bone Implants

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November 1, 2018

Khosravi N, Mendes VC, Nirmal G, Majeed S, DaCosta R, Davies J; Tissue Eng Part C Methods. 2018 Nov;24(11):617-627
doi: 10.1089/ten.TEC.2018.0252

Nanosurfaces Modulate the Mechanism of Peri-Implant Endosseous Healing by Regulating Neovascular Morphogenesis

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June 1, 2018

Khosravi N, Maeda A, DaCosta RS, Davies JE; Nat Comm Bio. 72(1):2399-3642
doi: 10.1038/s42003-018-0074-y

A Feasibility Study of Photoacoustic Imaging of Ex Vivo Endoscopic Mucosal Resection Tissues from Barrett’s Esophagus Patients

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August 7, 2017

Lim L, Streutker CJ, Marcon N, Cirocco M, Lao A, Iakovlev VV, DaCosta R, Wilson BC; Endosc Int Open. 2017 Aug;5(8):E775-E783
doi: 10.1055/s-0043-111790

Improved Detection of Clinically Relevant Wound Bacteria Using Autofluorescence Image-Guided Sampling in Diabetic Foot Ulcers

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February 28, 2017

Ottolino-Perry K, Chamma E, Blackmore KM, Lindvere-Teene L, Starr D, Tapang K, Rosen CF, Pitcher B, Panzarella T, Linden R, DaCosta RS; Int Wound J. 2017 Oct;14(5):833-841
doi: 10.1111/iwj.12717

Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging

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December 18, 2016

Stammes MA, Knol-Blankevoort VT, Cruz LJ, Feitsma HR, Mezzanotte L, Cordfunke RA, Sinisi R, Dubikovskaya EA, Maeda A, DaCosta RS, Bierau K, Chan A, Kaijzel EL, Snoeks TJ, van Beek ER, Löwik CW; Mol Imaging Biol. 2016 Dec;18(6):905-915
doi.org/10.1007/s11307-016-0972-7

The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death

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October 21, 2016

Stammes MA, Maeda A, Bu J, Scollard DA, Kulbatski I, Medeiros PJ, Sinisi R, Dubikovskaya EA, Snoeks TJ, van Beek ER, Chan AB, Löwik CW, DaCosta RS; Front Oncol. 2016 Oct 21;6:221
doi: 10.3389/fonc.2016.00221

Hybrid Manganese Dioxide Nanoparticles Potentiate Radiation Therapy by Modulating Tumor Hypoxia

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October 6, 2016

Abbasi AZ, Gordijo CR, Amini MA, Maeda A, Rauth AM, DaCosta RS, Wu XY; Cancer Res. 2016 Nov 15;76(22):6643-6656
doi: 10.1158/0008-5472.CAN-15-3475.

In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model

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September 14, 2016

Maeda A, Chen Y, Bu J, Mujcic H, Wouters BG, DaCosta RS; Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):184-194
doi: 10.1016/j.ijrobp.2016.09.005

Can Imaging Put the “Advanced” Back in Advanced Wound Care?

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August 1, 2016

DaCosta RS, Ottolino-Perry K, Banerjee J; Adv Wound Care (New Rochelle). 2016 Aug 1;5(8):329-331
doi: 10.1089/wound.2016.0702

Femur Window Chamber Model for In Vivo Cell Tracking in the Murine Bone Marrow

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July 28, 2016

Chen Y, Maeda A, Bu J, DaCosta RS; J Vis Exp. 2016 Jul 28;(113)
doi: 10.3791/54205.

Emerging Applications for Optically Enabled Intravital Microscopic Imaging in Radiobiology

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September 1, 2015

Maeda A, Kulbatski I, DaCosta RS; Mol Imaging. 2015 Sep 1;14:452-74
doi.org/10.2310/7290.2015.00022

Optically-Tracked Handheld Fluorescence Imaging Platform for Monitoring Skin Response in the Management of Soft Tissue Sarcoma

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July 1, 2015

Chamma E, Qiu J, Lindvere-Teene L, Blackmore KM, Majeed S, Weersink R, Dickie CI, Griffin AM, Wunder JS, Ferguson PC, DaCosta RS; J Biomed Opt. 2015 Jul 1;20(7):76011
doi: 10.1117/1.JBO.20.7.076011

Handheld Fluorescence Imaging Device Detects Subclinical Wound Infection in an Asymptomatic Patient with Chronic Diabetic Foot Ulcer: a Case Report

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April 15, 2015

Wu YC, Smith M, Chu A, Lindvere-Teene L, Starr D, Tapang K, Shekhman R, Wong O, Linden R, DaCosta RS; Int Wound J. 2016 13(4):449-53
doi: 10.1111/iwj.12451

A Prototype Hand-Held Tri-Modal Instrument for In Vivo Ultrasound, Photoacoustic, and Fluorescence Imaging

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March 27, 2015

Kang J, Chang JH, Wilson BC, Veilleux I, Bai Y, DaCosta RS, Kim K, Ha S, Lee JG, Kim JS, Lee S, Kim SM, Lee HJ, Ahn YB, Han S, Yoo Y and Song T; Rev. Sci. Instrum. 2015 (86)034901
doi.org/10.1063/1.4915146

Point-of-Care Autofluorescence Imaging for Real-Time Sampling and Treatment Guidance of Bioburden in Chronic Wounds: First-in-Human Results

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March 19, 2015

DaCosta RS, Kulbatski I, Lindvere-Teene L, Starr D, Blackmore K, Silver JI, Opoku J, Wu YC, Medeiros PJ, Xu W, Xu L, Wilson BC, Rosen C, Linden R; PLoS ONE 10(3): e0116623
doi.org/10.1371/journal.pone.0116623

Design of Hybrid MnO2-Polymer-Lipid Nanoparticles with Tunable Oxygen Generation Rates and Tumor Accumulation for Cancer Treatment,

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February 18, 2015

Gordijo CR, Abbasi AZ, Amini MA, Lip HY, Maeda A, Cai P, O’Brien PJ, DaCosta RS, Rauth AM and Wu XY; Advanced Functional Materials. 2015;25(12):1858–1872
doi.org/10.1002/adfm.201404511

Dual In Vivo Photoacoustic and Fluorescence Imaging of HER2 Expression in Breast Tumors for Diagnosis, Margin Assessment, and Surgical Guidance

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November 1, 2014

Maeda A, Bu J, Chen J, Zheng G, DaCosta RS; Mol Imaging 2014;13(0):1-9
doi: 10.2310/7290.2014.00043

A Multifunctional Polymeric Nanotheranostic System Delivers Doxorubicin and Imaging Agents Across the Blood-Brain Barrier Targeting Brain Metastases of Breast Cancer

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October 13, 2014

Li J, Cai P, Shalviri A, Henderson JT, He C, Foltz WD, Prasad P, Brodersen PM, Chen Y, DaCosta R, Rauth AM, Wu XY; ACS Nano. 2014 Oct 28;8(10):9925-40
doi: 10.1021/nn501069c

Autofluorescence Imaging Device for Real-Time Detection and Tracking of Pathogenic Bacteria in a Mouse Skin Wound Model: Preclinical Feasibility Studies

August 19, 2014

Wu YC, Kulbatski I, Medeiros PJ, Maeda A, Bu J, Xu L, Chen Y,DaCosta RS; J Biomed Opt. 2014 Aug;19(8):085002
doi: 10.1117/1.JBO.19.8.085002

Multifunctional Albumin Based MnO2 Nanoparticles Modulate Solid Tumor Microenvironment by Attenuating Hypoxia, Acidosis, VEGF and Enhance Radiation Response

April 4, 2014

Prasad P, Gordijo CR, Abbasi AZ, Maeda A, Ip A, Rauth AM, DaCosta RS and Wu XY; ACS Nano. 2014 8 (4), 3202-3212
doi: 10.1021/nn405773r

Tumour Vascularization is Critical for Oncolytic Vaccinia Virus Treatment of Peritoneal Carcinomatosis

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February 1, 2014

Ottolino-Perry K, Tang N, Head R, Ng C, Angarita FC, Acuna SA, DaCosta RS and McCart JA; Int J Cancer. 2014;134(3):717-30

doi.org/10.1002/ijc.28395

Advanced Imaging Technologies for the Detection of Dysplasia and Early Cancer in Barrett Esophagus

January 24, 2014

Espino A, Cirocco M, DaCosta RS, Marcon N; Clin Endosc. 2014 47(1): 47–54
doi:10.5946/ce.2014.47.1.47

Optimization of the Dorsal Skinfold Window Chamber Model and Multi-Parametric Characterization of Tumor-Associated Vasculature

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January 1, 2014

Maeda A, DaCosta RS; Intravital. 2014 Feb 4;3(1):e27935
doi:10.4161/intv.27935

Endoscopic Mucosal Imaging of Gastrointestinal Neoplasia in 2013

July 15, 2013

Urquart P, DaCosta RS, Marcon NE; Curr Gastroenterol Rep. 2013;15(7):330
doi: 10.1007/s11894-013-0330-8

A Novel High-Resolution In Vivo Imaging Technique to Study the Dynamic Response of Intracranial Structures to Tumor Growth and Therapeutics

June 16, 2013

Burrell K, Agnihotri S, Leung M, DaCosta RS, Hill RP, Zadeh G; J. Vis. Exp. 2013;(76), e50363
doi:10.3791/50363

Texture Analysis of OCT Speckle for Characterizing Biological Tissues In Vivo

April 15, 2013

A.A. Lindenmaier, L. Conroy, R.S. DaCosta, C. Flueraru, I.A. Vitkin; Opt Lett. 2013;38(8):1280-2

Texture Analysis of Optical Coherence Tomography Speckle for Characterizing Biological Tissues In Vivo

April 15, 2013

Lindenmaier AA, Conroy L, Farhat G, DaCosta RS, Flueraru C, Vitkin A; Opt Lett. 2013;38(8):1280-2
doi:10.1364/OL.38.001280

Serum-Free Differentiation of Functional Human Coronary-Like Vascular Smooth Muscle Cells from Embryonic Stem Cells

April 1, 2013

El-Mounayri O, Mihic A, Shikatani A, Gagliardi M, Dubois N, DaCosta RS, Li RK, Keller G, Husain M; Cardiovasc Res. 2013;98(1):125-35
doi:10.1093/cvr/cvs357

A Spinal Cord Window Chamber Model for In Vivo Longitudinal, Multimodal Optical Imaging in a Mouse Model

March 14, 2013

Figley SA, Chen Y, Maeda A, Conroy L, McMullen JD, Silver JI, Stapleton S, Vitkin A, Zadeh G, Burrell K, Fehlings MG, DaCosta RS. PLoS One. 2013;8(3):e58081
doi:10.1371/journal.pone.0058081

Displaying 3D Radiation Dose on Endoscopic Video for Therapeutic Assessment and Surgical Guidance

October 21, 2012

J. Qiu, A. Hope, J. Cho, M. Sharpe, C. Dickie, R.S. DaCosta, D.A. Jaffray and R. Weersink; Phys Med Biol. 2012;57(20):6601-14

A Novel Solid Lipid Nanoparticle Formulation for Active Targeting to Tumor αvβ3 Integrin Receptors Reveals Cyclic RGD as a Double-Edged Sword

September 12, 2012

A.J. Shuhendler, P. Prasad, M. Leung, A.M. Rauth, R.S. DaCosta, X.Y. Wu; Advanced Healthcare Materials. 2012; (5):600-8

In Vivo Optical Imaging of Tumor and Microvascular Response to Ionizing Radiation

August 22, 2012

A. Maeda, M.K.K. Leung, L. Conroy, Y. Chen, J. Bu, P.E. Lindsay, S. Mintzberg, C. Virtanen, J. Tsao, N.A. Winegarden, Y. Wang, L. Morikawa, I.A. Vitkin, D.A. Jaffray, R.P. Hill, R.S. DaCosta; PLoS ONE 2012;7(8)

Quantifying Tissue Microvasculature with Speckle Variance Optical Coherence Tomography

August 1, 2012

L. Conroy, R.S. DaCosta, I.A. Vitkin; Opt Lett. 2012;37(15):3180

Estimation of Minimum Doses for Optimized Quantum Dot Contrast-Enhanced Vascular Imaging In Vivo

June 11, 2012

M. Roy, C.J. Niu, Y. Chen, P.Z. McVeigh, A.J. Shuhendler, M.K.K. Leung, A. Mariampillai, R.S. DaCosta, B.C. Wilson; Small 2012;11:1780-92

Improving Superficial Target Delineation in Radiation Therapy with Endoscopic Tracking and Registration

December 12, 2011

Weersink RA, Qiu J, Hope AJ, Daly MJ, Cho EC, DaCosta RS, Sharpe MB, Breen SL, Chan H, Jaffray DA; Med Phys. 2011;38(12):6458
doi:10.1118/1.3658569

Aberrant Axial Mineralization Precedes Spinal Ankylosis: a Molecular Imaging Study in Ank/Ank Mice

October 12, 2011

Las Heras F, DaCosta RS, Pritzker KP, Haroon N, Netchev G, Tsui HW, Chiu B, Erwin WM, Tsui FW, Inman RD; Arthritis Res Ther. 2011;13(5):R163
doi:10.1186/ar3482
F Las Heras, R.S. DaCosta, K.P. Pritzker, N. Haroon, G. Netchev, H.W. Tsui, B. Chiu, W.M. Erwin, F.W. Tsui, R.D. Inman; Arthritis Res Ther. 2011;13(5):R163

Directed Differentiation of Skin-Derived Precursors into Functional Vascular Smooth Muscle Cells

August 18, 2011

Steinbach SK, El-Mounayri O, DaCosta RS, Frontini MJ, Nong Z, Maeda A, Pickering JG, Miller FD, Husain M; Arterioscler Thromb Vasc Biol. 2011;13(5):R163
doi:10.1161/ATVBAHA.111.232975

Porphyrin-Cross-Linked Hydrogel for Fluorescence-Guided Monitoring and Surgical Resection

July 21, 2011

Lovell JF, Roxin A, Ng KK, Qiaochu QQ, McMullen JD, DaCosta RS, Zheng G; Biomacromolecules. 2011;12(9):3115-8
doi:10.1021/bm200784s

Design and Modeling of a Prototype Fiber Scanning CARS Endoscope

February 24, 2010

Veilleux I, Doucet M, Coté P, Verreault S, Fortin M, Paradis P, Leclair S, DaCosta RS, Wilson BC, Seibel E, Mermut O, Cormier J; Design and modeling of a prototype fiber scanning CARS endoscope, Proc. SPIE 7558, Endoscopic Microscopy V, 75580D (24 February 2010)

doi:10.1117/12.842624

Extending Immunofluorescence Detection Limits in Whole Paraffin-Embedded Formalin Fixed Tissues using Hyperspectral Confocal Fluorescence Imaging

May 2, 2009

Constantinou P, DaCosta RS, Wilson BC; J Microsc. 2009;234:137-46
doi: 10.1111/j.1365-2818.2009.03155.x

Integrated Biophotonics in Endoscopic Oncology

February 24, 2009

Muguruma N, DaCosta RS, Wilson BC, Marcon NE; Integrated biophotonics in endoscopic oncology, Proc. SPIE 7170, Design and Quality for Biomedical Technologies II, 71700B (24 February 2009)
doi:10.1117/12.806591

In Vivo Near-Infrared Fluorescence Imaging of Human Colon Adenocarcinoma by Specific Immunotargeting of a Tumor-Associated Mucin

January 1, 2009

DaCosta RS, Tang Y, Kalliomaki T, RM Reilly, Weersink RA, Elford AR, Marcon NE, Wilson BC; Journal of Innovative Optical Health Sciences 2009; 2:1-16; Journal of Innovative Optical Health Sciences 2009; 2:1-16
doi:10.1142/S1793545809000759