Timothy Samuel

Current title:
PhD Candidate
Degrees:
Honours Bachelor of Science in Physics, University of Toronto, Canada
Affiliations:

  • Department of Medical Biophysics, Faculty of Medicine, University of Toronto
  • Princess Margaret Cancer Centre, University Health Network

Biography

Tim joined our lab in 2017 and is currently pursuing his PhD in the Department of Medical Biophysics at the University of Toronto.

Research

This image was captured in a live mouse using a laser-scanning confocal microscope (LSM710, Carl Zeiss). The pancreatic tumor (blue), blood vessels (green), and pancreatic stellate cells (pink) are visualized.

Stereotactic Body Radiation Therapy (SBRT) is an emerging treatment for locally-advanced pancreatic cancer.  While most therapeutic strategies focus on the cancer cell itself, many studies are showing that coordinated communication between cancer cells and their surrounding microenvironment exert a more profound effect on the development of malignancy and treatment resistance. My preclinical project is looking at the effects of SBRT on the in vivo pancreatic tumor microenvironment using fluorescence intravital microscopy.

Key Publications

Assessing the Accuracy of Bioluminescence Image-Guided Stereotactic Body Radiation Therapy of Orthotopic Pancreatic Tumors Using a Small Animal Irradiator

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Our recent publication in Radiation Research, “Assessing the Accuracy of Bioluminescence Image-Guided Stereotactic Body Radiation Therapy of Orthotopic Pancreatic Tumors Using a Small Animal Irradiator” is a collaboration between the DaCosta Lab and Dr. Robert Weersink. In this preclincal study, Dr. Sara Rapic (former Post-doctoral fellow) and Timothy Samuel (Ph.D. candidate) demonstrated the improved accuracy of using 3-dimensional bioluminescence…

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