2024

Our recent paper, “Investigating the Effects of Stereotactic Body Radiation Therapy on Pancreatic Tumor Hypoxia and Microvasculature in an Orthotopic Mouse Model using Intravital Fluorescence Microscopy,” was published in Scientific Reports (December 2024). Background and Aims: Despite decades of improvements in cytotoxic therapy, the current standard of care for locally advanced pancreatic cancer (LAPC) provides, on average, only a few months of survival benefit. Stereotactic Body Radiation Therapy (SBRT), a technique that accurately delivers high doses of radiation to tumors in fewer fractions, has emerged as a promising therapy to improve local control of LAPC; however, its effects on the…

Our recent paper, ““Glucagon-like-protein-2 stimulates lacteal contractility and enhances chylomicron transport in the presence of an intact enteric nervous system,” was published in Gastro Hep Advances (June 2024). Background and Aims: Secretion and transport of intestinal chylomicrons (CM) via lymphatics to the blood circulation is stimulated primarily by fat ingestion, whereas several other factors have also been shown to play important roles in regulating CM secretion rate. Amongst these factors, active regulation of lymphatic pumping has not been appreciated to date. The gut peptide and intestinal growth factor GLP-2 has emerged as a robust enhancer of intestinal lipid mobilization and…