The DaCosta Lab congratulates Dr. Timothy Samuel for successfully defending his PhD on May 2, 2023! His PhD thesis, entitled “In Vivo Effects of Stereotactic Body Radiation Therapy on the Pancreatic Tumor Microenvironment,” focuses on improving our understanding of how different elements of the pancreatic tumor microenvironment (e.g., tumor cells, blood vessels, oxygenation and collagen…

A representative image of an in vivo orthotopic BxPC3-DsRed-5xHRE/GFP tumor foci, taken using intravital fluorescence and SHG microscopy. BxPC3 cells (DsRed) are shown in red, HIF activity (5xHRE/GFP) in green, blood vessels (APC-CD31) in cyan, and fibrillar collagen (SHG) in white. Scale bars, 100 μm The DaCosta Lab is pleased to announce that our publication,…

Dr. Shirley Wang has been promoted to Clinical Research Coordinator II.  Dr. Wang has worked in the DaCosta lab since 2018, managing several clinical trials, namely the FLIGHT Phase IV trial, the ALA Breast Cancer Phase III trial, and the Wound Area Reduction trial. She has been responsible for ensuring project milestones are met, initiating…

Dr. Elyse Digby successfully defended her PhD thesis on April 4, 2023!  Her PhD research project focused on applying novel small molecule photosensitizers to improve the efficacy of PDT.  She studied the design of photosensitizers that would be selectively activated in cancers overexpressing certain enzyme targets (e.g.., human NAD(P)H quinone oxidoreductase 1), a photosensitizer that was…

Welcome, Lyndsey de Guzman, who joins the DaCosta Lab as a Masters student! Lyndsey completed a major in Bio-Medical Sciences and a minor in Business at the University of Guelph. Her undergraduate research project focused on the development of spontaneous osteoarthritis with a concentration of integrin α1β1 and the transforming growth factor beta. She used…

Welcome, Dr. Elyse Digby, who joins the DaCosta Lab as a Postdoctoral Fellow! Elyse obtained her PhD in Biological Chemistry from Dr. Andrew Beharry’s lab at the University of Toronto, Mississauga campus, where she designed, synthesized, and applied novel small molecule photosensitizers to enhance the efficacy and selectivity of photodynamic therapy against cancer.  Elyse will…

On November 5th 2022, the Department of Medical Biophysics held a virtual Open House to students who were interested in enrolling in a Masters or PhD program. Faculty and students across the department showcased their research to prospective students. If you are a student and are interested in joining our lab, refer to our poster…

Dr. DaCosta presented at the sixth edition of the Future Investment Initiative held in Riyadh, Saudi Arabia. This conference convened CEOs, policymakers, investors, entrepreneurs and young leaders from around the world. Dr. DaCosta participated in in-depth conversations about new pathways for global investment, analysis of critical industry trends, global energy crisis, and geopolitical conflicts that…

Chris was invited to give an oral presentation at the 2022 WMIC Conference in Miami Beach, Florida. For this trip, Chris won the SGS Conference Grant. At WMIC, he presented “First-in-human intra-cavity imaging of 5-ALA-induced fluorescence during breast cancer surgery.” The purpose of Chris’ talk was to present both the strengths and shortfalls (with potential…

Michael and Emily were invited to present a poster at the WMIC 2022 Conference in Miami Beach, Florida. They presented “Quantitative Intravital Imaging for Real-time Monitoring of Pancreatic Tumor Cell Hypoxia and Stroma in an Orthotopic Mouse Model,” which discussed the investigation of the spatial and temporal influence hypoxia on the pancreatic tumor microenvironment in…