We are pleased to share that our grant submission to the Cancer Research Society 2024 Operating Grant Competition titled, “AML Dynamics in the Bone Marrow: Probing Treatment Impact Using Intravital Imaging,” has been awarded funding.
The Cancer Research Society is a pan-Canadian not-for-profit organization that funds research on all types of cancer to help prevent, detect, and treat the disease. It supports “innovative projects involving creativity and original ideas, because it is through research that the solutions to cancer will be discovered.”
Our project, “AML Dynamics in the Bone Marrow: Probing Treatment Impact Using Intravital Imaging,” has the potential to provide new knowledge about the in vivo time course of AML remodeling of the BM niche in an unprecedented manner. The proposed experiments will show us how the disease enters and expands within the BM and how this progression changes the vasculature and oxygenation of the BM. In addition, we will learn if, and to what extent, such alterations impact the behavior of human immune cells in vivo. Importantly, we will understand how such disease-induced BM remodeling and immune cell changes impact treatment effectiveness. Using a humanized mouse model for our proposed research will more accurately reflect the human immune response towards the disease, making our results more translationally relevant.