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Abstract Clinical wound assessment involves microbiological swabbing of wounds to identify and quantify bacterial species, and to determine microbial susceptibility to antibiotics. The Levine swabbing technique may be suboptimal because it samples only the wound bed, missing other diagnostically relevant areas of the wound, which may contain clinically significant bacteria. Thus, there is a clinical need to improve the reliability of microbiological wound sampling. To address this, a handheld portable autofluorescence (AF) imaging device that detects bacteria in real time, without contrast agents, was developed. Here, we report the results of a clinical study evaluating the use of real-time AF…

Fluorescence imaging of microscopic GFP metastatic colonic tumor cells in mouse lung. Fluorescence imaging during resection of GFP tumor in mouse model. Fluorescence imaging of GFP orthotopic colonic tumor (arrow) in mouse abdomen. The Moleculight RD:100, developed in the Dacosta lab, is now available to scientists around the world! In vivo fluorescence imaging of small animals in preclinical research is used widely across a variety of disciplines such as oncology and infectious disease.  It provides a means of detecting a fluorescent signal within a living animal reflecting specific, mostly disease-related, processes, such as parts of the host immune response, inflammation,…