Summary of Scientific Presentation: Ralph da Costa, “Investigating Radiation Response of Pancreatic Tumors, Their Vasculature and Microenvironment Using in Vivo Imaging to Identify New Treatment Strategies” While stereotactic body radiotherapy (SBRT) shows promise for local control SBRT-induced vascular dysfunction, hypoxia are barriers. Candidate hypoxia-activated prodrugs (AQ4N) show potential, but require optimization. Newly discovered oxygen-generating nanoparticles (OGNPs) could be a clinical ‘game changer’ if tumor re-oxygenation with OGNPs enhanced AQ4N tumor cell cytotoxicity. To explore this potential, a novel preclinical optically-based imaging platform was developed that combines experimental microirradiation and advanced intravital imaging. The platform will be used to also investigate…
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