2021

Intraoperative Fluorescence Imaging with Aminolevulinic Acid Decets Grossly Occult Breast Cancer: A Phase II Randomized Controlled Trial is published in Breast Cancer Research
 970 1030 DaCosta Lab

After a lengthy journey, our paper “Intraoperative fluorescence imaging with aminolevulinic acid detects grossly occult breast cancer: a phase II randomized controlled trial” has been published in Breast Cancer Research as an open access article. The journal is widely read globally by general surgeons and breast cancer clinicians, so we are pleased it will receive broad clinical exposure and impact specifically in (breast) surgical oncology. This trial, led by Dr. DaCosta, was conducted at The Princess Margaret Cancer Center (Toronto, Canada) and demonstrates the importance of strong collaborations between our (imaging) scientists and clinicians at the Princess Margaret Cancer Center.  For…

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Intraoperative Fluorescence Imaging with Aminolevulinic Acid Detects Grossly Occult Breast Cancer: A Phase II Randomized Controlled Trial: Manuscript accepted to Breast Cancer Research
 1030 606 DaCosta Lab

In 2009, the first patient was enrolled at Princess Margaret Cancer Center in this Phase II randomized controlled trial led by Dr. DaCosta in collaboration with surgeons Drs. Wey Leong and Alexandra Easson and pathologist Dr. Susan Done. The goal was to evaluate the clinical safety, feasibility and diagnostic performance of the PRODIGI handheld fluorescence imaging device combined with 5-ALA HCl for intraoperative visualization of invasive breast carcinomas. The Phase II trial was supported in large part by a $3M CIHR grant awarded to the DaCosta lab. Today, over a decade later, the manuscript for this study was accepted for…

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In Vivo Mesenchymal Progenitor Cell Dynamics: Dr. Niloufar Khosravi publishes in Biomaterials
 818 807 DaCosta Lab

Niloufar Khosravi, a DaCosta Lab PhD student alumna, published in Biomaterials today: “New insights into spatio-temporal dynamics of mesenchymal progenitor cell ingress during peri implant wound healing: Provided by intravital imaging”. Abstract Surface topography drives the success of orthopedic and dental implants placed in bone, by directing the biology occurring at the tissue-implant interface. Over the last few decades, striking advancements have been made in the development of novel implant surfaces that enhance bone anchorage to their surfaces through contact osteogenesis: the combination of the two phenomena of recruitment and migration of mesenchymal progenitor cells to the implant surface, and…

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