Research

We develop advanced molecular imaging solutions to improve diagnosis, treatment and monitoring of therapeutic response in cancer and other diseases.

Preclinical Research

The DaCosta research team develops new optical imaging tools, in the fields of intravital microscopy and molecular probes, which are used in specialized animal models of human cancers. These innovative tools enable us to visualize and quantify biological processes and therapy-induced changes in the living tumor. We capture a tumor’s dynamic microenvironment in vivo, over time, at single cell level producing award winning images.

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Clinical Research

The DaCosta lab is focused on bringing innovative solutions to clinical problems with the goal of improving patient care and outcomes. We rely on our clinical partners to frame the problems patients and clinicians experience today and look to offer effective, easily implementable solutions. The DaCosta lab is focused on developing diagnostic, treatment monitoring and guidance imaging tools for use in clinics and operating rooms.

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Clinical Trials

The DaCosta lab has completed over six PI-sponsored medical device clinical trials at UHN and collaborating centers across the Greater Toronto Area. From first-in-human prototype testing, to interventional device trials, our multidisciplinary team has extensive experience moving new devices from our translation research team through clinical testing across multiple indications with a focus on oncology and diabetic wound healing.

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Our Multidisciplinary

Team

Meet the Team

News

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Lyndsey de Guzman joins the DaCosta Lab as a Masters student

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February 22, 2023

Welcome, Lyndsey de Guzman, who joins the DaCosta Lab as a Masters…

Dr. Elyse Digby wins the NSERC Postdoctoral Fellowship award and joins the DaCosta Lab as a Postdoctoral Fellow

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February 22, 2023

Welcome, Dr. Elyse Digby, who joins the DaCosta Lab as a Postdoctoral…

DaCosta Lab presents at the MBP Virtual Open House

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November 29, 2022

On November 5th 2022, the Department of Medical Biophysics held a virtual…

Publications

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Assessing the Accuracy of Bioluminescence Image-Guided Stereotactic Body Radiation Therapy of Orthotopic Pancreatic Tumors Using a Small Animal Irradiator

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April 14, 2022

Our recent publication in Radiation Research, “Assessing the Accuracy of Bioluminescence Image-Guided…

Intraoperative Fluorescence Imaging with Aminolevulinic Acid Decets Grossly Occult Breast Cancer: A Phase II Randomized Controlled Trial is published in Breast Cancer Research

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July 21, 2021

After a lengthy journey, our paper “Intraoperative fluorescence imaging with aminolevulinic acid…

Dr. DaCosta to Deliver Keynote Presentation at St Michael’s 4th Annual Life Sciences Career Symposium

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June 8, 2021

The St. Michael’s Hospital Research Student Association’s annual Life Sciences Career Symposium…