COSTA LAB Translationally-Driven Molecular Imaging Molecular imaging has the potential to transform healthcare globally. D A

Research

We develop advanced molecular imaging solutions to improve diagnosis, treatment and monitoring of therapeutic response in cancer and other diseases.

Preclinical

Preclinical Research

The DaCosta research team develops new optical imaging tools, in the fields of intravital microscopy and molecular probes, which are used in specialized animal models of human cancers. These innovative tools enable us to visualize and quantify biological processes and therapy-induced changes in the living tumor. We capture a tumor’s dynamic microenvironment in vivo, over time, at single cell level producing award winning images.

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Clinical Research

The DaCosta lab is focused on bringing innovative solutions to clinical problems with the goal of improving patient care and outcomes. We rely on our clinical partners to frame the problems patients and clinicians experience today and look to offer effective, easily implementable solutions. The DaCosta lab is focused on developing diagnostic, treatment monitoring and guidance imaging tools for use in clinics and operating rooms.

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Clinical Trials

The DaCosta lab has completed over six PI-sponsored medical device clinical trials at UHN and collaborating centers across the Greater Toronto Area. From first-in-human prototype testing, to interventional device trials, our multidisciplinary team has extensive experience moving new devices from our translation research team through clinical testing across multiple indications with a focus on oncology and diabetic wound healing.

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Our Multidisciplinary

Team

Meet the Team
DaCosta Team photo

News

DaCosta Lab attends WMIC 2020 virtually
1030 630 DaCosta Lab

The DaCosta lab attended this year’s World Molecular Imaging Conference from October…

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DaCosta and Minden Labs Awarded CIHR Grant
1030 576 DaCosta Lab

Drs. Ralph DaCosta and Mark Minden have been awarded a 4-year CIHR…

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Publications

Engineering Functional Microvessels in Synthetic Polyurethane Random-Pore Scaffolds by Harnessing Perfusion Flow
1030 1019 DaCosta Lab

Wright ME, Yu JK, Jain D, Maeda A, Yeh SA, DaCosta R, Lin CP, Santerre JS; Biomaterials. 2020 Jun 23;256:120183
doi: 10.1016/j.biomaterials.2020.120183. Online ahead of print.

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Intraoperative Fluorescence Imaging with Aminolevulinic Acid Detects Grossly Occult Breast Cancer: a Phase II Randomized Controlled Trial (Conference Presentation)
838 680 DaCosta Lab

Ottolino-Perry K, Shahid A, DeLuca S, Son V, Liu Z, Rapic S, Thalanki Anantha NWang S, Chamma E, Blackmore K, Gibson C, Medeiros PJ, Majeed S, Chu A, Pizzolato A, Rosen CF, Lindvere-Teene L, Dunham D, Kulbatski I, Panzarella T, Done SJ, Easson AM, Leong WL, DaCosta RS; Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110701Y (14 August 2019)

doi.org/10.1117/12.2527216

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Intravital Imaging for Tracking of Angiogenesis and Cellular Events Around Surgical Bone Implants
1030 780 DaCosta Lab

Khosravi N, Mendes VC, Nirmal G, Majeed S, DaCosta R, Davies J; Tissue Eng Part C Methods. 2018 Nov;24(11):617-627
doi: 10.1089/ten.TEC.2018.0252

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Collaborations

Academic

Industry

Funding