We are pleased to announce a recent publication, “Customizable optical tissue phantom platform for characterization of fluorescence imaging device sensitivity,” in the Journal of Biomedical Optics.
Link to publication: https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-28/issue-8/086004/Customizable-optical-tissue-phantom-platform-for-characterization-of-fluorescence-imaging/10.1117/1.JBO.28.8.086004.full
Authors: Dr. Christopher Gibson, Arcturus Phoon, Dr. Ralph S. DaCosta
Abstract: Optical tissue phantoms serve as inanimate and stable reference materials used to calibrate, characterize, standardize, and test biomedical imaging instruments. Although various types of solid tissue phantoms have been described in the literature, current phantom models are limited in that they do not have a depth feature that can be adjusted in real-time, they cannot be adapted to other applications, and their fabrication can be laborious and costly.
Our goal was to develop an optical phantom that could assess the imaging performance of fluorescence imaging devices and be customizable for different applications. We developed a phantom with three distinct components, each of which can be customized.
We present a method for fabricating a solid optical tissue that contains (1) an adjustable depth capability using thin film phantoms, (2) a refillable chip loaded with fluorophores of the user’s choice in various desired quantities, and (3) phantom materials representative of different tissue types.