News

http://www.ncbi.nlm.nih.gov/pubmed/?term=Emerging+Applications+for+Optically+Enabled+Intravital+Microscopic+Imaging+in+Radiobiology  

http://www.newswire.ca/news-releases/moleculight-announces-health-canada-approval-for-the-moleculight-ix-its-first-diagnostic-medical-imaging-device-for-wound-care-534693261.html  

http://caho-hospitals.com/innovative-technology-by-moleculight-inc-poised-to-revolutionize-chronic-wound-care/  

Summary of Scientific Presentation: Ralph da Costa, “Investigating Radiation Response of Pancreatic Tumors, Their Vasculature and Microenvironment Using in Vivo Imaging to Identify New Treatment Strategies” While stereotactic body radiotherapy (SBRT) shows promise for local control SBRT-induced vascular dysfunction, hypoxia are barriers. Candidate hypoxia-activated prodrugs (AQ4N) show potential, but require optimization. Newly discovered oxygen-generating nanoparticles (OGNPs) could be a clinical ‘game changer’ if tumor re-oxygenation with OGNPs enhanced AQ4N tumor cell cytotoxicity. To explore this potential, a novel preclinical optically-based imaging platform was developed that combines experimental microirradiation and advanced intravital imaging. The platform will be used to also investigate…

Aceel Hawa, Summer Science Discovery Intern (2014) at the DaCosta Lab and Grade 12 Toronto French School student, has been named one of the University of Toronto’s National Scholars for 2015. The university receives thousands of applications annually from across Canada and, after a rigorous set of interviews, 10 recipients are selected. The scholarship consists of four undergraduate years at the university, paid for in full. In her application, Aceel described her summer internship at our cutting-edge research lab and reflected upon her risks, successes and failures, which confirmed her commitment to the process of conducting scientific research. Aceel is…

During July and August, the DaCosta lab hosted Nir Livneh, a visiting medical student from Tel Aviv University as part of a collaboration with Prof. Ilan Tsarfaty’s molecular imaging lab from Israel (http://www2.tau.ac.il/nano/researcher.asp?id=aghihfeif). Nir worked with the clinical research team, and contributed to the planning of a clinical study that will assess the ability of a hand held autofluorescence imaging device (PRODIGI) to detect bacteria in burn wounds and predict impairements in the healing process. Nir hopes to leverage his experience to build new academic bridges between the University of Toronto and Tel Aviv University.

Optically-tracked handheld fluorescence imaging platform for monitoring skin response in the management of soft tissue sarcoma. Chamma E, Qiu J, Lindvere-Teene L, Blackmore KM, Majeed S, Weersink R, Dickie CI, Griffin AM, Wunder JS, Ferguson PC, DaCosta RS. J Biomed Opt. 2015 Jul 1;20(7):76011. doi: 10.1117/1.JBO.20.7.076011    

Emerging Applications for Optically-enabled Intravital Microscopic Imaging in Radiobiology Maeda A., Kulbatski I., and DaCosta R. IN PRESS  

Handheld fluorescence imaging device detects subclinical wound infection in an asymptomatic patient with chronic diabetic foot ulcer: a case report. http://onlinelibrary.wiley.com/doi/10.1111/iwj.12451/abstract;jsessionid=8504439B4A8F8F18181B125564949C48.f04t04

http://research2reality.com/headlines/see-the-invisible/