Dr. DaCosta participates in Annual 2021 MBP Career Symposium

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The annual MBP Symposium (which combines the James Lepock Memorial (JLM) Symposium and the annual MBP Alumni Night) is an important MBP event that provides an opportunity for MBP students to present their research in a conference setting. The MBP Symposium fosters scientific debate across disciplines, streams and institutes. MBP students have the opportunity to…

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Dr. Niloufar Khosravi featured on U of T Faculty of Dentistry Website

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Niloufar Khosravi, a DaCosta Lab PhD student alumna was recently featured on U of T’s Faculty of Dentistry site. In the Article, “U of T Researchers Map Regenerative Cells in Implant Wounds” Niloufar summarized her work recently published in Biomaterials.

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Intraoperative Fluorescence Imaging with Aminolevulinic Acid Detects Grossly Occult Breast Cancer: A Phase II Randomized Controlled Trial: Manuscript accepted to Breast Cancer Research

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In 2009, the first patient was enrolled at Princess Margaret Cancer Center in this Phase II randomized controlled trial led by Dr. DaCosta in collaboration with surgeons Drs. Wey Leong and Alexandra Easson and pathologist Dr. Susan Done. The goal was to evaluate the clinical safety, feasibility and diagnostic performance of the PRODIGI handheld fluorescence…

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World’s 1st Patient Surgery in Pivotal Phase III breast cancer trial

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  Today marks an important milestone for SBI Canada’s Phase III RCT entitled “Fluorescence Imaging of Carcinoma During Breast Conserving Surgery”, as the first patient surgery was performed successfully at Orlando Health in Orlando, Florida. (ClinicalTrials.gov Identifier: NCT04815083) This trial utilizes the tumor selectivity of 5-ALA combined with the handheld Eagle fluorescence imaging device to…

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Helen Jin is going to Medical School!

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We would like to congratulate Helen Jin on her acceptance into the University of Western Ontario MD Program, knowing she was also accepted to several other prestigious MD programs across Canada. Helen joined the DaCosta Lab in 2019 to pursue her MSc in the Department of Medical Biophysics, UofT and will be graduating in June…

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World’s 1st Patient Enrolled in International FDA Approved Phase III RCT of Breast Cancer Surgery

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Today, SBI ALApharma Canada Inc., a subsidiary of photonamic GmbH & Co. KG (Pinneberg, Germany), a subsidiary of SBI Holdings, Inc. (Minato-ku, Tokyo) announced it has enrolled the first patient in its Pivotal Phase III randomized controlled trial evaluating the safety and efficacy of PD G 506 A (5-ALA HCl) in margin assessment during breast…

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Fluorescence-Guided Breast Cancer Surgery: International Pivotal Phase III RCT receives FDA IND Clearance

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Today, SBI ALApharma Canada Inc., a subsidiary of photonamic GmbH & Co. KG ( Pinneberg, Germany), a subsidiary of SBI Holdings, Inc. (Minato-ku, Tokyo); received FDA Investigational New Drug (IND) clearance for its Pivotal Phase III randomized controlled trial (RCT) evaluating the safety and efficacy of PD G 506 A (5-ALA HCl) in intraoperative margin assessment during…

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In Vivo Mesenchymal Progenitor Cell Dynamics: Dr. Niloufar Khosravi publishes in Biomaterials

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Niloufar Khosravi, a DaCosta Lab PhD student alumna, published in Biomaterials today: “New insights into spatio-temporal dynamics of mesenchymal progenitor cell ingress during peri implant wound healing: Provided by intravital imaging”. Abstract Surface topography drives the success of orthopedic and dental implants placed in bone, by directing the biology occurring at the tissue-implant interface. Over…

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Arcturus Phoon Promoted To Research Analyst

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We would like to congratulate Arcturus Phoon on his recent promotion to Clinical Research Analyst! His hard work and eagerness to take on responsibility is demonstrated every day, and helps propel the DaCosta Lab to new heights. We hope to see Mr. Phoon around the lab for years to come and wish him all the…

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Dr. DaCosta discusses the origins of the lab and his serendipitous invention in UHN’s latest Behind the Breakthrough podcast episode

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Behind the Breakthrough, a podcast about the people behind the world-leading research at UHN, features Dr. Ralph DaCosta in Episode 7 of its second season. In this episode, Dr. DaCosta recollects his family’s immigration to Canada, his career path and serendipitous discovery that could revolutionize wound care. Hear about his groundbreaking work in visualizing cancer, his adventure…

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