New Publication in the BioMed Central Journal

600 750 DaCosta Lab

We are pleased to announce an upcoming publication, “A handheld device for intra-cavity and ex vivo fluorescence imaging of breast conserving surgery margins with 5-aminolevulinic acid,” in the BioMed Central Journal.

Link to publication: Coming soon

Authors: Christopher Gibson, Shirley C. Wang, Arcturus Phoon, Nayana Thalanki Anantha, Kathryn Ottolino-Perry, Stephen Petropoulos, Zuha Qureshi, Vasanth Subramanian, Anam Shahid, Cristiana O’Brien, Steven Carcone, Suzanne Chung, Teresa Tsui, Viktor Son, Mayleen Sukhram, Fannong Meng, Susan J. Done, Alexandra M. Easson, Tulin Cil, Michael Reedijk, Wey L. Leong and Ralph S. DaCosta.

Abstract:: Visualization of cancer during breast conserving surgery (BCS) remains challenging; the BCS reoperation rate is reported to be 20-70% of patients. An urgent clinical need exists for real-time intraoperative visualization of breast carcinomas during BCS. We previously demonstrated the ability of a prototype imaging device to identify breast carcinoma in excised surgical specimens administration following 5-aminolevulinic acid (5-ALA) administration. However, this prototype device was not designed to image the surgical cavity for remaining carcinoma after the excised lumpectomy is removed. A new handheld fluorescence (FL) imaging prototype device, designed to image both excised specimens and within the surgical cavity, was assessed in a clinical trial to evaluate its clinical utility for first-in-human, real-time intraoperative imaging during index BCS.